The U.S.S. Madison is a Galaxy-class cruiser in service to Starfleet in 2410.
- Motra (captain)
- Erickson (first officer)
- Shelby (conn officer)
- J'rone (tactical officer)
- "The Sentinels of Andor": The Madison is sent to study Taris's base in the Hobus System but comes under attack from a renegade mirror universe Andorian ship, the Sentinel. After the player's engineering officer takes command, the Madison becomes trapped in an alternate timeline and is ultimately destroyed by two Reman warbirds while covering the player's escape. The I.S.S. Basilisk rescues a dozen survivors, including the acting captain, before following the player through the temporal rift.